The Effect of Pulmonary Surfactant Drugs Combined with High-Flow Na-sal Cannula Humidification Oxygen Therapy on Respiratory Function and Adverse Reactions in Newborns with Pneumonia and Respiratory Failure After Mechanical Ventilation Withdrawal
Objective To analyze the effects of pulmonary surfactant drugs combined with high flow nasal cannula hu-midified oxygen therapy(HFNC)on respiratory function and adverse reactions in newborns with pneumonia compli-cated with respiratory failure after mechanical ventilation withdrawal.Methods A total of 80 neonates with pneumonia complicated with respiratory failure admitted to the Department of Pediatrics,Lianjiang County Hospital from January 2021 to December 2023 were randomly selected as the research objects.They were divided into two groups by differ-ent treatment methods,with 40 cases in each group.The control group was treated with pulmonary surfactant drugs af-ter weaning from mechanical ventilation,and the study group was treated with HFNC on the basis of the control group.The respiratory function index,blood gas index and adverse reactions of the two groups were analyzed.Results After treatment,the oxygenation index of the study group was higher than that of the control group,and the respiratory rate and ventilation volume were lower than those of the control group,the differences were statistically significant(all P<0.05).After treatment,the blood gas indexes of the study group were higher than those of the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the study group was 5.00%(2/40),which was lower than 25.00%(10/40)in the control group,and the difference was statistically significant(χ2=4.804,P=0.028).Conclusion The combination of pulmonary surfactant drugs and HFNC therapy has potential benefits in improving respiratory function and reducing the incidence of adverse reactions in newborns with pneumonia and re-spiratory failure after mechanical ventilation withdrawal.
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