Clinical Efficacy Study of Aspirin in High-risk Pregnant Women with Pre-eclampsia
Objective To investigate the effect of aspirin on pregnancy outcomes in pregnant women at high risk of pre-eclampsia(PE).Methods The clinical data of 203 pregnant women with high risk of PE who underwent regular prena-tal examination in the Fifth Affiliated Hospital of Guangzhou Medical University from December 2020 to October 2023 were retrospectively selected.According to whether they took aspirin or not,they were divided into control group and study group,105 cases in control group and 98 cases in study group.The control group received routine prenatal ex-amination,and the study group received aspirin 100 mg daily on the basis of the control group.The pregnancy out-come,neonatal outcome and changes of coagulation function before and after treatment were compared between the two groups.Results The incidence of preeclampsia in the study group was 4.08%(4/98),and the incidence of severe preeclampsia was 2.04%(2/98),which were lower than 12.38%(13/105)and 9.52%(10/105)in the control group,the differences were statistically significant(χ2=4.550,5.103,both P<0.05).There was no significant difference in the mode of delivery,the incidence of placental abruption and postpartum hemorrhage between the two groups(P>0.05).The incidence of fetal growth restriction and premature birth rate in the study group were lower than those in the con-trol group,and the birth weight of the newborn was higher than that in the control group,the differences were statisti-cally significant(all P<0.05).There was no significant difference in neonatal asphyxia rate between the two groups(P>0.05).After treatment,there was no significant difference in prothrombin time,activated partial thrombolasin time,D-dimer between the two groups(all P>0.05),the fibrinogen and the platelet count in the study group were lower than those in the control group,the differences were statistically significant(both P<0.05).Conclusion Aspirin can reduce the incidence of PE in pregnant women at high risk of preeclampsia and improve adverse neonatal outcomes.
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