Clinical Efficacy of Ticagrelor Combined with Tirofiban in the Treatment of Acute Myocardial Infarction
Objective To investigate the clinical effect of ticagrelor combined with tirofiban in the treatment of acute myocardial infarction.Methods A total of 52 patients with acute myocardial infarction(AMI)admitted to Xiapu County Hospital of Fujian Province from January 2021 to December 2023 were conveniently selected as the research subjects and divided into control group and observation group according to different medication regimens,with 26 cases in each group.Both groups were treated with conventional drugs.On this basis,the control group was treated with tirofiban,and the observation group was treated with ticagrelor combined with tirofiban.The clinical efficacy,car-diac function,inflammatory factor levels,platelet indexes and complications were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.15%(25/26),which was higher than 73.08%(19/26)in the control group,and the difference was statistically significant(χ2=5.318,P<0.05).After treat-ment,the left ventricular ejection fractions(LVEF)and stroke volume(SV)in the observation group were higher than those in the control group,and the left ventricular end-diastolic volume(LVEDV)and left ventricular systolic volume(LVESV)were lower than those in the control group,the differences were statistically significant(all P<0.05).After treatment,levels of the platelet aggregation rate,platelets(PLT),C-reactive protein(CRP)and interleukin-6(IL-6)in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The total incidence of complications in the observation group was lower than that in the control group,the dif-ference was statistically significant(P<0.05).Conclusion Ticagrelor combined with tirofiban has a significant clinical effect in the treatment of AMI,which can effectively reduce platelet aggregation rate,reduce inflammation,improve cardiac function and reduce the risk of complications.
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