摘要
目的 分析绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)患者椎体压缩性骨折(vertebial com-pression fractures,VCF)发生率、危险因素及干预对策.方法 简单随机选取2021年5月—2023年5月浙江省人民医院毕节医院收治的60例PMOP患者为研究对象,统计其VCF发生率;另收集患者的基线资料,采用单因素和多因素非条件Logistic回归分析法筛选出VCF发生的相关危险因素.结果 60例PMOP患者中,VCF发生率为23.33%(14/60);单因素分析结果显示:两组糖尿病史、骨密度异常降低、日照时间、体育锻炼时间、钙摄入量、雌激素替代治疗比较,差异有统计学意义(P均<0.05).多因素Logistic回归分析结果显示:有糖尿病史(OR=17.417,95%CI:3.937～77.043)、骨密度异常降低(OR=13.714,95%CI:2.705～69.533)、日照时间<1 h/d(OR=6.346,95%CI:1.686～23.883)、体育锻炼时间<1 h/d(OR=6.480,95%CI:1.769～23.740)、钙摄入量<1 000 mg/d(OR=7.429,95%CI:1.966～28.075)、无雌激素替代治疗(OR=8.381,95%CI:2.020～34.768)是PMOP患者VCF发生的独立危险因素(P均<0.05).结论 有糖尿病史、骨密度异常降低、日照时间<1 h/d、体育锻炼时间<1 h/d、钙摄入量<1 000 mg/d、无雌激素替代治疗为PMOP患者VCF发生的独立危险因素.
Abstract
Objective To analyze the incidence,risk factors and intervention strategies of vertebral compression frac-tures(VCF)in patients with postmenopausal osteoporosis(PMOP).Methods Sixty PMOP patients admitted to Zhejiang Provincial People's Hospital Bijie Hospital from May 2021 to May 2023 were simple randomly selected as the re-search objects.The incidence of VCF was counted;in addition,the baseline data of the patients were collected,and univariate and multivariate unconditional Logistic regression analysis methods were used to screen out the relevant risk factors for the occurrence of VCF.Results Among the 60 patients with PMOP,the incidence of VCF was 23.33%(14/60);the results of univariate analysis showed that there were significant differences in diabetes history,abnormal reduction of bone mineral density,sunshine time,physical exercise time,calcium intake and estrogen replacement therapy between the two groups(all P<0.05).The results of Logistic regression analysis showed that having diabetes history(OR=17.417,95%CI:3.937～77.043),having abnormally decreased bone mineral density(OR=13.714,95%CI:2.705～69.533),sunshine duration<1 h/d(OR=6.346,95%CI:1.686～23.883),physical exercise time<1 h/d(OR=6.480,95%CI:1.769～23.740),calcium intake<1 000 mg/d(OR=7.429,95%CI:1.966～28.075),and no estrogen re-placement therapy(OR=8.381,95%CI:2.020～34.768)were independent risk factors for the occurrence of VCF in PMOP patients(all P<0.05).Conclusion Having diabetes history,abnormally decreased bone mineral density,sun-shine duration<1 h/d,physical exercise time<1 h/d,calcium intake<1 000 mg/d,and no estrogen replacement therapy are independent risk factors for the occurrence of VCF in PMOP patients.
NETL
NSTL
万方数据