Analysis of the Effect of High-flow Nasal Cannula Oxygen Therapy Com-bined with Non-invasive Respiratory Ventilation on Patients with Severe Pneumonia and Respiratory Failure
Objective To explore the effect of high-flow nasal cannula oxygen therapy(HFNC)combined with non-invasive positive pressure ventilation(NIPPV)on patients with severe pneumonia(SP)and respiratory failure.Meth-ods The clinical data of 120 SP patients with respiratory failure who were treated in Zibo 148 Hospital from March 2020 to March 2023 were retrospectively selected.According to the different treatment plans,they were divided into control group and observation group,with 60 cases in each group.The observation group was treated with HFNC com-bined with NIPPV,and the control group was treated with NIPPV.The clinical efficacy,arterial blood gas indexes,in-flammatory indexes and adverse reactions were compared between the two groups.Results After 2 weeks of treatment,the total effective rate of treatment in the observation group was 96.67%(58/60),which was higher than 83.33%(50/60)of the control group,and the difference was statistically significant(χ2=5.926,P=0.015).The levels of pulse oxy-gen saturation,partial pressure of oxygen and potential of hydrogen in the observation group were higher than those in the control group,and partial pressure of carbon dioxide in artery was lower than that in the control group,the differ-ence was statistically significant(all P<0.05).The levels of C-reactive protein,interleukin-1 and tumor necrosis fac-tor-α in the observation group were lower than those in the control group,and the differences were statistically signifi-cant(all P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion HFNC combined with NIPPV can improve the clinical efficacy of SP patients with respiratory failure,improve arterial blood gas indexes and inflammatory indexes,and reduce the incidence of adverse reactions.
Severe pneumoniaRespiratory failureHigh-flow nasal cannula oxygen therapyNon-invasive poshtiue pressure ventilationInflammatory markersArterial blood gas indicators
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