The Effect of Fuyuan Hezhong Tang Combined with Acupoint Application on Serum T Lymphocyte Subsets and Tumor Markers in Gastric Cancer Patients Undergoing SOX Chemotherapy
Objective To analyze the effect of Fuyuan Hezhong Tang decoction combined with acupoint application on serum T lymphocyte subsets and tumor markers in patients with gastric cancer undergoing SOX chemotherapy.Meth-ods A total of 94 gastric cancer patients treated with SOX chemotherapy in Jinan Integrated Traditional Chinese and Western Medicine Hospital from February 2021 to February 2023 were conveniently selected as the research objects.According to different treatment methods,they were divided into two groups,with 47 cases in each group.The control group was treated with Fuyuan Hezhong Tang,the observation group was treated with Fuyuan Hezhong Tang combined acupoint application,21 d as a course of treatment,continuous treatment for 4 courses.The clinical efficacy,T lym-phocyte subsets,tumor marker levels and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of CD3+,CD4+and CD8+between the two groups(all P>0.05);after treatment,CD3+and CD4+in observation group were(55.61±3.97)%and(45.97±3.52)%,higher than those in control group(49.70±3.25)%and(38.64±2.83)%,and CD8+were(19.84±1.25)%,lower than those in control group(23.11±1.67)%,and the differences were statistically significant(t=7.897,11.126,10.747,all P<0.001).Before treatment,there was no significant difference in the level of tumor markers be-tween the two groups(P>0.05);after treatment,the carcinoembryonic antigen of the observation group was(6.40±0.94)ng/mL,carbohydrate antigen 242 was(28.35±1.88)U/mL,carbohydrate antigen 199 was(41.39±3.27)U/mL,carbohy-drate antigen 724 was(9.21±1.05)U/mL,which were lower than those of control group(8.53±1.25)ng/mL,(35.41±2.19)U/mL,(46.58±4.05)U/mL,(14.38±1.67)U/mL,and the differences were statistically significant(t=9.337,16.769,6.836,17.968,all P<0.001).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Fuyuan Hezhong Tang combined with acupoint application can improve the im-mune function and reduce the level of tumor markers in patients with gastric cancer treated with SOX chemotherapy,without serious adverse reactions.
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