度洛西汀联合重复经颅磁刺激治疗在老年抑郁症中的应用分析
Application Analysis of Duloxetine Combined with Repetitive Transcranial Magnetic Stimulation in the Treatment of Senile Depression
汪玉梅 1杨霞1
作者信息
- 1. 厦门市第五医院,福建 厦门 361000
- 折叠
摘要
目的 分析老年抑郁症患者采用度洛西汀联合重复经颅磁刺激方式治疗的临床疗效.方法 随机选取2020年1月—2023年1月厦门市第五医院收治的80例老年抑郁症患者为研究对象,根据不同治疗方法分为常规组和观察组,各40例.常规组采用度洛西汀治疗,观察组采用度洛西汀联合重复经颅磁刺激治疗,比较两组的抑郁病情、认知功能、不良反应发生率.结果 治疗后,观察组的抑郁量表评分低于常规组,差异有统计学意义(P<0.05).治疗后,观察组的认知功能优于常规组,差异有统计学意义(P<0.05).观察组和常规组的不良反应总发生率分别为7.50%(3/40)和12.50%(5/40),两组比较,差异无统计学意义(χ2=0.139,P>0.05).结论 度洛西汀联合重复经颅磁刺激治疗老年抑郁症,可有效改善患者病情及认知功能,且不会增加不良反应.
Abstract
Objective To analyze the clinical efficacy of duloxetine combined with repetitive transcranial magnetic stimulation in elderly patients with depression.Methods A total of 80 elderly patients with depression admitted to Xia-men Fifth Hospital from January 2020 to January 2023 were randomly selected as the research objects.According to different treatment methods,they were divided into conventional group and observation group,with 40 cases in each group.The conventional group was treated with duloxetine,and the observation group was treated with duloxetine com-bined with repetitive transcranial magnetic stimulation.The depression,cognitive function and the incidence of ad-verse reactions of the two groups were compared.Results After treatment,the depression scale score of the observation group was lower than that of the conventional group,and the difference was statistically significant(P<0.05).After treatment,the cognitive function of the observation group was better than that of the conventional group,and the differ-ence was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group and the conventional group was 7.50%(3/40)and 12.50%(5/40),respectively,there was no significant difference between the two groups(χ2=0.139,P>0.05).Conclusion Duloxetine combined with repetitive transcranial magnetic stimulation in the treatment of senile depression can effectively improve the patient's condition and it does not increase adverse reac-tions.
关键词
度洛西汀/重复经颅磁刺激/抑郁症/老年患者/治疗效果Key words
Duloxetine/Repetitive transcranial magnetic stimulation/Depression/Elderly patients/Treatment effect引用本文复制引用
出版年
2024
NETL
NSTL
万方数据