Efficacy of Dexamethasone Plus Levofloxacin in the Treatment of Suppura-tive Otitis Media and its Influence On The Level of Inflammatory Factors in Patients
Objective To investigate the application effect of dexamethasone combined with levofloxacin in the treat-ment of patients with suppurative otitis media and its effect on the level of inflammatory factors.Methods A total of 82 patients with suppurative otitis media admitted to the Department of Otorhinolaryngology,Zhongshan District People's Hospital of Liupanshui City from January 2022 to April 2024 were conveniently selected as the research objects.Ac-cording to different treatment drugs,they were divided into two groups,41 cases in each group.The control group was treated with levofloxacin,and the observation group was treated with dexamethasone+levofloxacin.The levels of in-flammatory factors,hearing indexes,clinical efficacy and the incidence of adverse reactions were compared between the two groups before and after treatment.Results After treatment,the levels of tumor necrosis factor-ɑ,interleukin-6,C-reactive protein,procalcitonin and transforming growth factor-β1 in the observation group were lower than those in the control group,and the bone conduction hearing loss,air conduction hearing loss,500 Hz hearing threshold,1 000 Hz hearing threshold and 2 000 Hz hearing threshold were lower than those in the control group,the differences were statistically significant(all P<0.05).The total effective rate of treatment in the observation group was 92.68%(38/41),which was higher than 75.61%(31/41)in the control group,the difference was statistically significant(χ2=4.479,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of dexamethasone and levofloxacin in the treatment of suppurative otitis media can ac-tively reduce the level of inflammatory factors and improve hearing indexes,with good efficacy and high safety.
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