Effect of Bronchoscopy Lavage on Serum Cytokines and Clinical Efficacy in Patients with Severe Pulmonary Infection
Objective To investigate the effects of bronchoscopy lavage on serum cytokines and clinical efficacy in pa-tients with severe pulmonary infection.Methods 80 patients with critically ill pulmonary infection treated in Xishui County People's Hospital of Guizhou Province from May 2021 to June 2023 were randomly selected as the study ob-jects.According to the different treatment methods were divided into two groups,40 cases each.The control group re-ceived conventional treatment,and the observation group,on the basis of the control group,used perfusion therapy with bedside bronchoscopy lavage.The levels of tumor necrosis factor-α(TNF-α)before treatment,24 h and 72 h af-ter treatment,changes in lung function and arterial oxygen partial pressure before and after treatment,and the dura-tion of ventilator therapy were compared between the two groups.Results At 24 h and 72 h after treatment,the TNF-α levels in the observation group were(12.6±1.6)ng/L and(8.1±0.7)ng/L,which were lower than those in the control group(27.4±4.3)ng/L and(15.1±2.1)ng/L,and the differences were statistically significant(t=20.402,20.000;both P<0.05).After treatment,the forced expiratory volume of the first second in the observation group was(56.8±2.9)%,the ratio of forced expiratory volume of the first second to forced vital capacity was(61.5±3.5)%,and the level of arterial blood oxygen partial pressure was(86.5±8.7)mmHg,which were higher than the control group(46.5±2.1)%,(52.3±3.1)%,(71.1±4.2)mmHg,the differences were statistically significant(t=18.194,12.445,10.082;all P<0.05).The treatment time of invasive ventilator in observation group was(4.1±1.0)d,and that of noninvasive ventilator was(5.6±1.8)d,which were shorter than those of control group(6.2±1.4)d and(8.9±2.7)d,the differences were statis-tically significant(t=7.720,6.432;both P<0.05).Conclusion Ronchoscopy lavage can effectively reduce inflammatory factors,improve lung function and oxygenation,and shorten the time of ventilator treatment in patients with severe pul-monary infection.
万方数据
维普
