Analysis of the Effects of Recombinant Human Growth Hormone Com-bined with calcium Gluconate Oral Solution on Bone Metabolism Indica-tors and Growth and Development in Children with Dwarfism
Objective To analyze the clinical efficacy of calcium gluconate oral solution combined with recombinant human growth hormone in the treatment of children with dwarfism.Methods A total of 100 children with short stature who were treated in the Department of Pediatrics of the Zhangzhou Second Hospital from May 2022 to May 2023 were randomly selected as the research objects.They were divided into two groups according to different treatment methods,with 50 cases in each group.The control group was treated with calcium gluconate oral solution,and the observation group was treated with calcium gluconate oral solution combined with recombinant human growth hormone.The growth and development indexes,bone metabolism indexes and adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in growth and development indexes between the two groups(P>0.05);after treatment,the height(129.86±4.84)cm,weight(22.86±2.08)kg,growth rate(7.83±1.51)cm/year and bone age(8.26±1.25)years in the observation group were higher than those in the control group(126.64±4.15)cm,(21.09±2.16)kg,(5.87±1.43)cm/year,(7.37±1.13)years,the differences were statistically significant(t=3.571,4.173,6.664,3.734;all P<0.05).After treatment,the bone metabolism indexes of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of calcium glu-conate oral solution combined with recombinant human growth hormone in the treatment of dwarfism can improve bone metabolism,promote its growth and development,and reduce drug adverse reactions.
DwarfismCalcium gluconate oral solutionRecombinant human growth hormoneGrowth and developmentBone metabolism
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