Analysis of Clinical Effect of Eltrombopag Combined with Cyclosporine in the Treatment of Primary Thrombocytopenia
Objective To analyze the clinical effect of treating patients with primary thrombocytopenia with eltrom-bopag and cyclosporine.Methods 60 patients with essential thrombocytopenia treated in the huai'an Fifth People's Hospital from March 2018 to March 2021 were randomly selected as the study objects,and were divided into control group and observation group according to different treatment methods,with 30 cases in each group.The control group was treated with cyclosporine,and the observation group combined with eltrombopag treatment.Platelet counts,inci-dence of adverse reactions,treatment effectiveness and quality of life scores were compared between the two groups before and after treatment.Results The effective rate of the observation group was 96.67%(29/30),which was higher than that of the control group 73.33%(22/30),the difference was statistically significant(χ2=4.706;P<0.05).The inci-dence of adverse reactions in observation group was lower than that in control group,and the difference was statisti-cally significant(P<0.05).There was no significant difference in platelet count between two groups before treatment and 3 months after treatment(both P>0.05).At 6 months after treatment,the platelet count in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).At 6 months after treatmen,the life quality score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The total effective rate and the incidence of adverse reactions in pa-tients with thrombocytopenia can be increased by the treatment of Altropopa+cyclosporine,and improve platelet lev-els,improve quality of life.
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