目的 探讨聚乙二醇干扰素联合丹膝颗粒对乙肝肝硬化患者的影响.方法 回顾性选取2021年6月—2023年4月福建省龙岩市第二医院收治的64例乙肝肝硬化患者的临床资料,按治疗方式的不同进行分组,采用恩替卡韦治疗的32例为对照组,采用聚乙二醇干扰素联合丹膝颗粒治疗的32例为研究组.比较两组乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)转阴率、临床疗效、炎性因子指标、肝脏弹性检测、肝功能、不良反应发生率.结果 研究组HBsAg转阴率、临床治疗总有效率分别为50.00%(16/32)、90.63%(29/32),均高于对照组的9.38%(3/32)、68.75%(22/32),差异有统计学意义(χ2=12.650,4.730;P均<0.05).治疗6个月后,研究组谷丙转氨酶、转化生长因子β1、肿瘤坏死因子-α、白细胞介素-6、肝脏弹性值、超敏C反应蛋白、总胆红素、天门冬氨酸氨基转移酶均低于对照组,差异均有统计学意义(P均<0.05).两组不良反应总发生率比较,差异无统计学意义(P>0.05).结论 应用聚乙二醇干扰素联合丹膝颗粒治疗乙肝肝硬化的效果显著,可促进改善患者肝功能,提高HBsAg转阴率,改变肝硬化结节,减轻炎性反应,促进肝功能恢复,且安全性高.
Efficacy Analysis of Pegylated Interferon Combined with Danxi Granules in Treatment of Hepatitis B Cirrhosis
Objective To investigate the effect of pegylated interferon combined with Danxi granule on patients with hepatitis B cirrhosis.Methods The clinical data of 64 patients with hepatitis B cirrhosis admitted to the Second Hospi-tal of Longyan,Fujian Province from June 2021 to April 2023 were retrospectively selected and grouped according to different treatment methods.32 patients treated with entecavir were used as the control group,and 32 patients treated with pegylated interferon combined with Danxi granules were used as the study group.The negative conversion rate of hepatitis B surface antigen(HBsAg),clinical efficacy,inflammatory factor index,liver elasticity test,liver function and the incidence of adverse reactions were compared between the two groups.Results The HBsAg negative conversion rate and total effective rate of clinical treatment in the study group were 50.00%(16/32)and 90.63%(29/32),respec-tively,which were higher than 9.38%(3/32)and 68.75%(22/32)in the control group,and the differences were statisti-cally significant(χ2=12.650,4.730;both P<0.05).After 6 months of treatment,alanine aminotransferase,transforming growth factor β1,tumor necrosis factor-α,interleukin-6,liver elasticity,high-sensitivity C-reactive protein,total bili-rubin,and aspartate aminotransferase in the study group were lower than those in the control group,and the differ-ences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse re-actions between the two groups(P>0.05).Conclusion The application of pegylated interferon combined with Danxi granule in the treatment of hepatitis B cirrhosis has a significant effect,which can promote the improvement of liver function,increase the HBsAg negative rate,change the cirrhosis nodules,reduce the inflammatory reaction,promote the recovery of liver function,and has high safety.
Hepatitis B virus related cirrhosisDanxi granulePegylated interferonhepatitis B surface antigenNegative rateInflammatory factorsLiver functionClinical effect
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