Efficacy of Octreotide Combined with Ulinastatin on Curative Effect and Intestinal Function in Patients with Severe Acute Pancreatitis
Objective To investigate the efficacy of octreotide combined with ulinastatin in the treatment of severe acute pancreatitis(SAP)and its effect on intestinal function.Methods A total of 70 SAP patients admitted to Nanping First Hospital of Fujian Province from April 2021 to September 2023 were randomly selected as the research objects.According to different treatment methods,they were divided into control group and observation group,with 35 cases in each group.The control group was treated with octreotide,and the observation group was treated with octreotide com-bined with ulinastatin.The efficacy,symptom control time,inflammatory factors and intestinal function of the two groups were compared.Results The effective rate of treatment in the observation group was 94.29%(33/35),which was higher than 77.14%(27/35)in the control group,and the difference was statistically significant(χ2=4.200;P=0.040).The control time of pancreatitis symptoms(abdominal pain,abdominal distension,nausea and vomiting)in the observation group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of C-reactive protein(CRP),procalcitonin(PCT)and white blood cell count(WBC)in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the recovery time of bowel sounds,the recovery time of anus exhaust and the recovery time of anus defecation in the observation group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Octreotide combined with ulinastatin in the treatment of SAP can im-prove the curative effect,accelerate the relief of pancreatitis symptoms,reduce the body's inflammatory response,and promote the recovery of intestinal function.
Severe acute pancreatitisOctreotideUlinastatinIntestinal functionInflammatory factor
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