Evaluation of the Effect of Doxycycline on Inflammatory Factor Indicators in the Treatment of Mycoplasma Pneumonia in Children
Objective To investigate the efficacy of doxycycline in the treatment of mycoplasma pneumonia in chil-dren.Methods A total of 108 children with mycoplasma pneumonia admitted to Shaowu Municipal Hospital of Fujian Province from January 2023 to March 2024 were conveniently selected as the research objects.According to different medication regimens,they were divided into control group and study group,54 cases in each group.The control group was treated with azithromycin sequential therapy,and the study group was treated with doxycycline on this basis.The clinical symptom relief time,inflammatory factor level and adverse reactions were compared between the two groups.Results The cough relief time(4.52±0.32)d,antipyretic time(2.92±0.27)d,rale duration(5.01±1.22)d,chest X-ray lesion absorption time(6.90±1.21)d and hospitalization time(9.29±1.26)d in the study group were shorter than those in the control group(6.20±1.16)d,(5.39±1.25)d,(7.18±1.41)d,(8.32±1.03)d and(11.48±1.14)d,the differences were statistically significant(t=10.259,14.193,8.552,6.567,9.471;all P<0.05).After treatment,the levels of inflam-matory factors in the two groups were lower than those before treatment,and the study group was lower than the con-trol group,the differences were statistically significant(both P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of doxycycline can pro-mote the improvement of inflammatory factors in children with mycoplasma pneumonia,and can accelerate the im-provement of clinical symptoms and promotion of children,the safety of medication is high.
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