摘要
肝移植作为治疗肝细胞肝癌的一种有效治疗方法,为不可切除肝细胞肝癌患者带来了新的希望.然而仍有许多超过移植标准的患者无法通过肝移植有效改善预后,降期治疗作为一种重要的治疗策略为上述患者提供了新的治疗策略.本综述以发表的文献作为基础,详细阐述不同降期治疗方案,如经导管肝动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)、钇-90微球经导管动脉放射栓塞(transarterial radio-embolization,TARE)、经皮乙醇注射(percutaneous ethanol injection,PEI)和肝癌射频消融术(radiofrequency ab-lation,RFA)等的基本治疗机制、适应证、禁忌证及纳排标准,以及不同降期治疗方案间的利弊和选择时机.
Abstract
Liver transplantation,as an effective treatment for hepatocellular carcinoma,has brought new hope to pa-tients with unresectable hepatocellular carcinoma.However,there are still many patients who exceed the transplanta-tion criteria and cannot effectively improve their prognosis through liver transplantation.Downward treatment,as an important treatment strategy,provides a new treatment strategy for these patients.This review is based on published literature and provides a detailed explanation of the basic treatment mechanisms,indications,contraindications,and inclusion/exclusion criteria for different downgrading treatment regimens,such as transcatheter arterial chemoemboli-zation(TACE),yttrium-90 microsphere transarterial radioembolization(TARE),percutaneous ethanol injection(PEI),and radio frequency ablation(RFA),as well as the advantages,disadvantages,and timing of different downgrading treatment regimens.
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