Progress on Downstaging Treatment of Liver Transplantation after Hepa-tocellular Carcinoma
Liver transplantation,as an effective treatment for hepatocellular carcinoma,has brought new hope to pa-tients with unresectable hepatocellular carcinoma.However,there are still many patients who exceed the transplanta-tion criteria and cannot effectively improve their prognosis through liver transplantation.Downward treatment,as an important treatment strategy,provides a new treatment strategy for these patients.This review is based on published literature and provides a detailed explanation of the basic treatment mechanisms,indications,contraindications,and inclusion/exclusion criteria for different downgrading treatment regimens,such as transcatheter arterial chemoemboli-zation(TACE),yttrium-90 microsphere transarterial radioembolization(TARE),percutaneous ethanol injection(PEI),and radio frequency ablation(RFA),as well as the advantages,disadvantages,and timing of different downgrading treatment regimens.
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