A method was developed for the simultaneous determination of 6 neonicotinoid insecticides and 3 organophosphorus insecticides including imidacloprid, acetamiprid, thiamethoxam, clothianidin, thiacloprid, dinotefuran, dimethoate, DDVP and chlorpyrifos in honey. The residues were extracted from the samples with acetonitrile and cleaned up with dispersive method on PSA, then detected by ultra liquid chromatography?mass spectrometry under multiple reaction monitoring mode, and quantified by matrix?match standard solution. The results showed the method had good linearity ( R≥0.994) from 5—800μg·L-1 . Average fortified recoveries in samples were in the range of 80. 4%—107. 5% at three fortified levels from 0. 005—0. 200 mg·kg-1 , with relative standard deviations of 1.2%—6.8% ( n=5) . The limits of detection ( LOD) of these 9 insecticides were in the range of 0.1—1.5 μg·kg-1, while limits of quantification (LOQ) were in the range of 0.3—4.5 μg·kg-1 . The method is rapid and simple with high sensitivity and good reproducibility, and suitable for determination of different insecticides in honey.
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