Identification and characterization on exogenous pollutants in the brain
The epidemiological researches have showed that long-term exposure to atmospheric fine particulate matter(PM2.5)pollution is an important factor for the occurrence and development of some brain diseases,e.g.,cerebrovascular and behavioral disorders,neurodegenerative diseases.Yet,the specific impact of exogenous particulate pollutants on the brain remains a"black box",which hinder assessing their brain risks scientifically.Here,we review the recent advances in the analysis of exogenous particulate pollutants in the brain.Moreover,this perspective proposes a comprehensive proposal(e.g.,non-targeted analysis,isotopic fingerprints)for identifying and tracing the exogenous PM in the brain.It is of extremely importance for elucidating the occurrence,exposure pathway,transportation,metabolism,and life cycle of PM in the brain.Hence,this method provides a powerful technological support for probing the disturbance mechanism of PM on some physiological functions and life processes of the brain in future studies.
万方数据
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