Research progresses of biotransformation mechanisms of bisphenols
Bisphenol A(BPA)and its substitutes,as representatives of phenolic compounds(BPs),have been widely detected in various environmental media,foods,consumer products,and human and animal bodies,indicating a pervasive global contamination trend.Beyond their inherent toxicity,BPs'transformation metabolites within organisms may exhibit more complex endocrine-disrupting and toxic effects than the parent compounds,with significant implications for human health.This paper presents a comprehensive review and summary of experimental and theoretical research methods employed in studying the biotransformation of BPs,along with the corresponding research findings.Furthermore,by examining the existing limitations and deficiencies in current studies,the paper provide insight into future research priorities.The elucidation of BPs'biological metabolism and its implications contributes to a better understanding of their potential risks and aids in the development of effective strategies for mitigating their adverse effects.
bisphenol pollutantsmetabolic transformationexperimental studytheoretical study
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