六氟环氧丙烷三聚体羧酸(HFPO-TA)污染现状和生物毒性研究进展
A review of contamination status and and biotoxicity of hexafluoropropylene oxide trimer acid(HFPO-TA)
刘梦琳 1王冰菁 1宿琪 1索秉旭 1冯精兰 1余浩1
作者信息
- 1. 河南师范大学环境学院,黄淮水环境污染与防治教育部重点实验室,河南省环境污染控制重点实验室,水处理关键技术国际联合实验室,新乡,453007
- 折叠
摘要
全氟/多氟化合物(per-and polyfluoroalkyl substances,PF AS)是一类具有优良表面活性和稳定性的有机化合物,广泛应用于工业和消费领域,全氟辛烷羧酸(perfluorooctanoic acid,PFOA)是具有代表性的一类PFAS.由于具有持久性、生物蓄积性、长距离迁移和生物毒性,PFOA已被限制生产和使用.六氟环氧丙烷三聚体羧酸(hexafluoropropylene oxide trimer acid,HFPO-TA)是一类新型的PFOA替代品.HFPO-TA在全球范围内的环境介质中广泛存在,在一些介质中的浓度接近甚至高于PFOA.HFPO-TA能在生物体内蓄积并可产生生物毒性效应,由于其独特的化学结构和理化性质,HFPO-TA的生物积累潜能和生物毒性强于PFOA.本文从HFPO-TA的生产、用途、环境归趋、环境介质和生物体内的污染现状、生物毒性和降解进行综述,并对未来研究趋势和发展方向进行展望,为研究HFPO-TA在生物体内富集与转化机制和毒理学评价提供参考依据.
Abstract
Per-and polyfluoroalkyl substances(PFAS)are a class of organic compounds with excellent surface activity and stability,which are widely used in industrial and consumer fields.Perfluorooctanoic acid(PFOA)is a representative class of PFAS.Duo to its persistence,bioaccumulation,long-distance migration and biological toxicity,PFOA has been restricted in production and use.Hexafluoropropylene oxide trimer acid(HFPO-TA)is a novel alternative to PFOA.HFPO-TA is widely distributed in environmental around the word,and its concentration in some media is close to or even higher than PFOA.HFPO-TA can accumulate in organisms and lead to biological toxicity.Due to its unique chemical structure and physical and chemical properties,HFPO-TA has stronger bioaccumulation potential and biological toxicity than PFOA.In this paper,the production,use,environmental fate,the pollution status in environmental medium and organisms,biotoxicity and degradation of HFPO-TA are reviewed,and the future research trend and development direction are prospected,providing reference basis for the study of enrichment and transformation mechanism of HFPO-TA in organisms and toxicological evaluation.
关键词
六氟环氧丙烷三聚体羧酸/多介质分布/生物富集/生物毒性/降解Key words
hexafluoropropylene oxide trimer acid/multimedia distribution/bioaccumulation/biotoxicity/degradation引用本文复制引用
基金项目
国家自然科学基金青年科学基金(42207427)
中国博士后科学基金(2022M711071)
河南师范大学博士科研启动基金(5101219170833)
河南师范大学博士后科研启动基金(5101219470248)
出版年
2024
NETL
NSTL
万方数据