A review of contamination status and and biotoxicity of hexafluoropropylene oxide trimer acid(HFPO-TA)
Per-and polyfluoroalkyl substances(PFAS)are a class of organic compounds with excellent surface activity and stability,which are widely used in industrial and consumer fields.Perfluorooctanoic acid(PFOA)is a representative class of PFAS.Duo to its persistence,bioaccumulation,long-distance migration and biological toxicity,PFOA has been restricted in production and use.Hexafluoropropylene oxide trimer acid(HFPO-TA)is a novel alternative to PFOA.HFPO-TA is widely distributed in environmental around the word,and its concentration in some media is close to or even higher than PFOA.HFPO-TA can accumulate in organisms and lead to biological toxicity.Due to its unique chemical structure and physical and chemical properties,HFPO-TA has stronger bioaccumulation potential and biological toxicity than PFOA.In this paper,the production,use,environmental fate,the pollution status in environmental medium and organisms,biotoxicity and degradation of HFPO-TA are reviewed,and the future research trend and development direction are prospected,providing reference basis for the study of enrichment and transformation mechanism of HFPO-TA in organisms and toxicological evaluation.
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