摘要
近年来,纳米氧化铈(CeO2NPs)独特的理化性质使其生产规模和应用范围逐渐扩大,但CeO2NPs在生产、运输和商品化过程中不可避免地被释放到环境中,具有环境污染的潜在风险,其生物安全性受到越来越多的关注.无脊椎动物是生物类群的重要组成,本文研究了国内外近十年的科学文献,综述了 CeO2NPs在生物累积、行为反应、组织损伤、生长发育毒性、免疫毒性、生殖毒性、遗传毒性等方面对无脊椎动物的影响以及CeO2NPs毒性效应影响因素,总结了 CeO2NPs对无脊椎动物的毒性机制,最后对未来研究方向进行了展望,以期为CeO2NPs的毒性评价、安全生产与应用提供参考.
Abstract
In recent years,due to the unique physicochemical properties of cerium oxide nanoparticles(CeO2NPs),the production scale and application range of these particles have gradually expanded.However,CeO2NPs are inevitably released into the environment during production,transportation,and commercialization,which can cause environmental pollution,and their biosafety has received increasing attention.Invertebrates are an important component of biological taxa.In this review,studies performed in China and other countries and published in the past 10 years are studied.The effects of CeO2NPs on invertebrates in terms of bioaccumulation,behavioral response,tissue damage,growth and development toxicity,immunotoxicity,reproductive toxicity,genotoxicity,and the influencing factors of CeO2NPs toxicity are reviewed.Furthermore,the toxicity mechanism of CeO2NPs in invertebrates is discussed.Finally,new research direction are proposed to study the toxicity,safe production,and application of CeO2NPs in the future.
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