微塑料对斑马鱼的毒性效应及机制研究进展
Research status of microplastics for zebrafish on the toxicity and mechanism
李昕桐 1丁平 2孙雅楠 1向重丹 1朱俊彦 2陈海波 3胡国成2
作者信息
- 1. 锦州医科大学研究生培养基地(生态环境部华南环境科学研究所),广州,510535;生态环境部华南环境科学研究所,国家环境保护环境污染健康风险评价重点实验室,广州,510535
- 2. 生态环境部华南环境科学研究所,国家环境保护环境污染健康风险评价重点实验室,广州,510535
- 3. 上海大学环境与化学工程学院,上海,200444
- 折叠
摘要
塑料污染已成为全球性重大环境问题,受到国际的广泛关注.2022年,我国将微塑料(microplastics,MPs)列为四大新污染物之一.MPs是指直径小于5 mm的塑料颗粒,具有生物毒性、环境持久性、生物累积性等特征,其生产和使用与人类生活息息相关,对生态环境和人体健康存在较大风险.在水环境中,MPs易被水生动物摄取产生毒性效应,并沿食物链富集和放大.斑马鱼是被广泛使用的毒理学模型,具有成本低、产卵率高、易饲养等特点,与人类的基因序列有很高的同源性.本文综述了国内外文章,阐述微塑料在斑马鱼体内的富集情况,归纳了微塑料对斑马鱼的生物毒性效应,总结了微塑料对斑马鱼的毒性作用机制,并从三个方面展望了未来的研究方向,为进一步开展微塑料的生物毒性效应、机制研究以及生态风险提供理论支撑和参考.
Abstract
Plastic pollution has grown into an important worldwide environmental issue,attracting broad international attention.In 2022,Microplastics(MPs)were classified as new pollutants in China.MPs are plastic particles with a diameter of less than 5 mm that are biotoxic,ecologically persistent,and bioaccumulative,and their manufacturing and usage are inextricably linked to human existence,providing a larger risk to the natural environment and human health.MPs are hazardous to aquatic creatures and are enhanced and amplified along the food chain in the aquatic environment.The zebrafish is a popular toxicological model due to its cheap expense,high spawning rates,ease of raising,and high degree of similarity with human DNA sequences.This paper reviews domestic and international articles,describes the enrichment of microplastics in zebrafish,summarizes the biotoxic effects of microplastics on zebrafish,concludes the mechanism of toxic effects of microplastics on zebrafish,and outlines future research directions from three perspectives,providing theoretical support and reference for further research on the biotoxic effects,mechanism,and ecological risks of microplastics.
关键词
微塑料/斑马鱼/毒性效应/毒性机制Key words
microplastics/zebrafish/toxicity/mechanism引用本文复制引用
基金项目
国家重点研发计划(2022YFC3902102)
出版年
2024
NETL
NSTL
万方数据