全氟和多氟烷基物质在人体生物样本中的检测方法与暴露水平研究进展
Progress in the determination methods and exposure levels of per-and polyfluoroalkyl substances in human biological samples
江建明 1李敏杰 1叶铖 2罗海威 3洪文俊 1郭良宏1
作者信息
- 1. 中国计量大学质量与安全工程学院,杭州,310018;中国计量大学环境与健康科学研究院,杭州,310018
- 2. 浙江交科环境科技有限公司,杭州,311305
- 3. 中国计量大学质量与安全工程学院,杭州,310018;上海安谱实验科技股份有限公司,上海,210609
- 折叠
摘要
全氟和多氟烷基物质(PFASs)是一类人工合成的化学物质,在环境介质和人体生物样本中被广泛检出.本文针对人体血液、尿液、母乳、头发和指甲等5种人体生物样本,总结了PFASs的前处理方法和仪器分析方法,介绍了国内外关于人体生物样本中PFASs暴露水平的最新研究进展,展望了这一领域的发展方向.通过研究结果显示,PFASs在普通人群5种样本中的检出情况为血液＞母乳＞尿液＞头发和指甲,人群的饮食特征、饮用水来源、研究区域工业化水平等均为影响PFASs暴露水平的重要因素,且研究发现从事相关行业的职业人群或相关行业周边居住居民其体内PFASs暴露水平比普通人群普遍高1-2个数量级.在5种人体生物样本中,PFOA和PFOS均为检出浓度较高的物质.本文旨在为今后关于PFASs的人体暴露和检测分析提供参考,为国家和地区人体生物监测提供技术支撑.
Abstract
Per-and polyfluoroalkyl substances(PFASs)are a class of synthetic chemicals,which are widely detected in environmental media and human biological samples.In this paper,the pretreatment methods and instrumental analysis methods of PFASs for five types of human biological samples,including human blood,urine,breast milk,hair and nails,were summarized.In addition,the latest research progress on the exposure level of PFASs in human biological samples at home and abroad is introduced,and the development direction in this field is prospected.The results of the study showed that PFASs were detected in five types of samples from the general population:blood＞breast milk＞urine＞hair and nails,and that the dietary characteristics of the population,the source of drinking water,and the level of industrialization in the study area were all important factors influencing the level of exposure to PFASs,and it was found that the level of exposure of occupational groups engaged in the relevant industries or living in the vicinity of the relevant industries was generally one to two orders of magnitude higher than that of the general population.In addition,it was found that the exposure level of PFASs in the occupational groups or residents living in the vicinity of the relevant industries was one to two orders of magnitude higher than that in the general population.PFOA and PFOS were detected at high concentrations in five types of human biological samples.This paper aims to provide reference for human exposure and detection analysis of PFASs in the future,and provide technical support for national and regional human biological monitoring.
关键词
全氟和多氟烷基物质/人体生物样本/检测方法/暴露水平Key words
per-and polyfluoroalkyl substances/human biological samples/detection method/exposure level引用本文复制引用
基金项目
国家自然科学基金(U20A20133)
国家自然科学基金(42107426)
出版年
2024
NETL
NSTL
万方数据