Health risk ranking of antibiotic resistance genes in the Yangtze River

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外文摘要：Antibiotic resistance is an escalating global health concern,exacerbated by the pervasive presence of antibiotic resistance genes(ARGs)in natural environments.The Yangtze River,the world's third-longest river,traversing areas with intense human activities,presents a unique ecosystem for studying the impact of these genes on human health.Here,we explored ARGs in the Yangtze River,examining 204 samples from six distinct habitats of approximately 6000 km of the river,including free-living and particle-associated settings,surface and bottom sediments,and surface and bottom bank soils.Employing shotgun sequencing,we generated an average of 13.69 Gb reads per sample.Our findings revealed a significantly higher abundance and diversity of ARGs in water-borne bacteria compared to other habitats.A notable pattern of resistome coalescence was observed within similar habitat types.In addition,we developed a framework for ranking the risk of ARG and a corresponding method for calculating the risk index.Applying them,we identified water-borne bacteria as the highest contributors to health risks,and noted an increase in ARG risks in particle-associated bacteria correlating with heightened anthropogenic activities.Further analysis using a weighted ARG risk index pinpointed the Chengdu-Chongqing and Yangtze River Delta urban agglomerations as regions of elevated health risk.These insights provide a critical new perspective on ARG health risk assessment,highlighting the urgent need for strategies to mitigate the impact of ARGs on human health and to preserve the ecological and economic sustainability of the Yangtze River for future human use.

外文关键词：

Antibiotic resistance genesYangtze RiverHabitatCoalescenceHealth risk

作者：

Chunxia Jiang、Zelong Zhao、Hans-Peter Grossart、Feng Ju、Yi Zhao、Geoffrey Michael Gadd、Ewa Korzeniewska、Yuyi Yang

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作者单位：

Key Laboratory of Aquatic Botany and Watershed Ecology,Wuhan Botanical Garden,Chinese Academy of Sciences,Wuhan,430074,China

University of Chinese Academy of Sciences,Beijing,100049,China

Danjiangkou Wetland Ecosystem Field Scientific Observation and Research Station,Chinese Academy of Sciences & Hubei Province,Wuhan,430074,China

Liaoning Key Laboratory of Marine Fishery Molecular Biology,Liaoning Key Lab of Germplasm Improvement and Fine Seed Breeding of Marine Aquatic Animals,Liaoning Ocean and Fisheries Science Research Institute,Dalian,116023,China

Leibniz-Institute for Freshwater Ecology and Inland Fisheries(IGB),Neuglobsow,16775,Germany

Institute for Biochemistry and Biology,Potsdam University,Potsdam,14469,Germany

Key Laboratory of Coastal Environment and Resources of Zhejiang Province,School of Engineering,Westlake University,Hangzhou 310030,China

School of Water Resources and Environment,China University of Geosciences(Beijing),Beijing 100083,China

Geomicrobiology Group,School of Life Sciences,University of Dundee,Dundee,DD1 5EH,Scotland,UK

State Key Laboratory of Heavy Oil Processing,State Key Laboratory of Petroleum Pollution Control,China University of Petroleum,Beijing,102249,China

Department of Water Protection Engineering and Environmental Microbiology,Faculty of Geoengineering,University of Warmia and Mazury in Olsztyn,Olsztyn,10-720,Poland

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出版年：

2024

DOI：

10.1016/j.ese.2024.100388

环境科学与生态技术(英文)

ISSN：

年,卷(期)：2024.21(5)