Gut pathobiome mediates behavioral and developmental disorders in biotoxin-exposed amphibians

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外文摘要：Emerging evidence suggests a link between alterations in the gut microbiome and adverse health out-comes in the hosts exposed to environmental pollutants.Yet,the causal relationships and underlying mechanisms remain largely undefined.Here we show that exposure to biotoxins can affect gut patho-biome assembly in amphibians,which in turn triggers the toxicity of exogenous pollutants.We used Xenopus laevis as a model in this study.Tadpoles exposed to tropolone demonstrated notable develop-mental impairments and increased locomotor activity,with a reduction in total length by 4.37％-22.48％and an increase in swimming speed by 49.96％-84.83％.Fusobacterium and Cetobacterium are predom-inant taxa in the gut pathobiome of tropolone-exposed tadpoles.The tropolone-induced developmental and behavioral disorders in the host were mediated by assembly of the gut pathobiome,leading to transcriptome reprogramming.This study not only advances our understanding of the intricate in-teractions between environmental pollutants,the gut pathobiome,and host health but also emphasizes the potential of the gut pathobiome in mediating the toxicological effects of environmental contaminants.

外文关键词：

Gut microbiomePathobiomeBiotoxin pollutionDevelopmental toxicityBehavioral disorders

作者：

Qianqian Pan、Tianxing Lv、Haorong Xu、Hongda Fang、Meng Li、Jiaping Zhu、Yue Wang、Xiaoyan Fan、Ping Xu、Xiuguo Wang、Qiangwei Wang、Haruna Matsumoto、Mengcen Wang

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作者单位：

Ministry of Agricultural and Rural Affairs Laboratory of Molecular Biology of Crop Pathogens and Insects,Zhejiang University,Hangzhou,310058,China

Institute of Pesticide and Environmental Toxicology,College of Agriculture and Biotechnology,Zhejiang University,Hangzhou,310058,China

Institute of Pesticide And Environmental Toxicology,College of Agriculture and Biotechnology,Zhejiang University,Hangzhou 310058,China

Institution of Tea Science,Zhejiang University,Hangzhou,310058,China

The Tobacco Research Institute,Chinese Academy of Agricultural Sciences,Qingdao,266101,China

Global Education Program for AgriScience Frontiers,Graduate School of Agriculture,Hokkaido University,Sapporo,Japan

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出版年：

2024

DOI：

10.1016/j.ese.2024.100415

环境科学与生态技术(英文)

ISSN：

年,卷(期)：2024.21(5)