With rapid development of high quality and sophisticated equipment,the demand of high quality,high depth/radius radio micro-holes is more and more urgent.Femtosecond laser and water-jet guided laser drilling technologies are introduced.Firstly,the principles of two kinds of micro-holes machining technologies are discussed and two kinds of micro-holes drilling technology research status are reviewed;Then,the effects of processing mode,laser process parameters,processing environment (vacuum,gas,liquid,chemical environment) and laser beam coupling with water on the micro-hole drilling quality are discussed;Finally,aerospace application of two kinds of micro-hole machining technologies and current problems which we face are summed up.