Objective To investigate the effects of daglipzin on the clinical efficacy and quality of life of elderly patients with type 2 diabetes mellitus(T2DM)combined with ejection fraction preserving heart failure(HFpEF).Methods A total of 200 elderly T2DM patients with HFpEF admitted to the First Affiliated Hospital of Jinzhou Medical University from December 2021 to May 2022 were selected as samples and divided into observation group(n=100)and control group(n=100)according to the"random sampling method".Both groups received conventional anti-heart failure treatment,while the control group received conventional diabetes treatment.The observation group was treated with daglipzine on the basis of the control group,and the cardiac function indexes,related clinical data,re-hospitalization rate and incidence of adverse reactions were compared between the two groups after 6 months of treatment.Indicators of the two groups were monitored:(1)Echocardiographic indicators(modified Simpson method)included:LVEF,LVEDD,left ventricular end-systolic diameter(LVESD),mitral valve maximum peak velocity at early diastolic stage,mitral valve maximum peak velocity at late diastolic stage;(2)Laboratory indicators include:N-terminal B-type natriuretic peptide precursor(NT-proBNP),fasting blood glucose(FPG),2 hours postprandial blood glucose(2hPG),and HbA1c;(3)6-minute walking distance(6MWD);(4)The quality of life of the patients was evaluated by the Minnesota Heart Dysfunction Quality of Life Scale(MLHFQ).Adverse events were monitored:(1)major cardiovascular adverse events(MACE)(cardiac death,re-hospitalization due to myocardial infarction,readmission due to heart failure,etc.);(2)General adverse reactions(urinary tract infection,hypoglycemia,gastrointestinal reactions,etc.).Results(1)After 6 months of treatment,LVEDD,LVESD,maximum mitral valve diastolic late peak flow rate,NT-proBNP and MLHFQ scores in 2 groups were significantly decreased compared with before(P＜0.05),and maximum mitral valve diastolic early peak flow rate and 6-minute walking distance(6MWD)were significantly increased compared with before treatment(P＜0.05).The observation group was significantly better than the control group(P＜0.05).(2)After 6 months of treatment,the total effective rate of the not use dagliazine group(97.00％)was significantly higher than that of Daglizine group(88.00％)(P＜0.05).(3)Adverse reactions:①The incidence of MACE in observation group(5.00％)was lower than that in control group(15.00％),and the difference was statistically significant(P＜0.01).(2)The incidence of adverse reactions in the observation group(4.00％)was less than that use Daglizine group(12.00％),and the difference was statistically significant(P＜0.05).Conclusions Daglipzine can improve the diastolic function and quality of life in elderly patients with T2DM combined with HFpEF,prolong the 6-minute walking distance(6MWD),and has good safety.
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