Olapalil Combined with Platinum-containing Chemotherapy Regimen Maintained the Efficacy of Plati-num-sensitive Advanced Ovarian Cancer
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目的 分析奥拉帕利联合含铂类化疗方案维持治疗铂敏感晚期卵巢癌的效果.方法 选取本院2021年04月-2023年04月间50例铂敏感晚期卵巢癌患者作为观察对象,按照化疗方案不同,分为对照组(TP化疗)和观察组[TP(紫杉醇+顺铂)+奥拉帕利)],各25例,比较应用效果.结果 观察组总有效率高于对照组(P＜0.05);两组不良反应无统计学意义(P＞0.05);观察组血清人附睾蛋白 4(Serum human epididymal protein 4,HE4)、转铁蛋白(Transferrin,SF)、糖类抗原CA(CA125)、CA199低于对照组(P＜0.05);观察组基质细胞衍生因子(Stromal cell derived factors,SDF-1α)、基质金属蛋白酶-9(Matrix metalloproteinase-9,MMP-9)、血管生成素-2(Angiopoietin-2,Ang-2)低于对照组(P＜0.05);观察组B淋巴细胞瘤-2(B lymphoblastoma-2,Bel-2)、可溶性细胞凋亡因子(Soluble apoptosis factor,sFas)、Bel-2 结合抗凋亡基因-1(Bcl-2 binds to anti-apoptotic gene-1,Bag-1)低于对照组,Bel-2相关X蛋白(Bel-2 associated X protein,Bax)高于对照组(P＜0.05).结论 TP+奥拉帕利与单纯TP化疗方案相比,在治疗铂敏感晚期卵巢癌中的疗效更加显著,且不增加不良反应,促进细胞凋亡,抑制血管形成,可推广.
Objective To analyze the efficacy of olapalil combined with platinum-containing chemotherapy regimen in the maintenance treatment of platinum-sensitive advanced ovarian cancer.Methods Fifty patients with platinum-sensitive advanced ovarian cancer from April 2021 to April 2023 were selected as the observation objects.According to different chemotherapy regimen,they were divided into control group(TP chemotherapy)and observation group[TP(paclitaxel+cisplatin)+olapalil)],25 cases each,and the application effect was compared.Results The total effective rate of observation group was higher than that of control group(P＜0.05).There was no statistical significance in adverse reactions between the two groups(P＞0.05).Serum human epididymal protein 4(HE4),Transferrin(SF),carbohydrate antigen CA(CA125)and CA199 in the observation group were lower than those in the control group(P＜0.05).Observation group Stromal cell derived factors(SDF-α),Matrix metalloproteinase-9(MMP-9),Angiopoietin-2(Angiopoietin-2)Ang-2)was lower than that of control group(P＜0.05).Observation group B lymphoblastoma-2(Bcl-2),Soluble apoptosis factor,soluble apoptosis factor,sFas),Bel-2 binds to anti-apoptotic gene-1(Bag-1)lower than the control group,and Bel-2 associated X protein(Bcl-2 associated X protein,Bel-2 associated X protein,Bel-2 binds to anti-apoptotic Gene-1(bag-1)lower than the control group.Bax was higher than that of control group(P＜0.05).Conclusions TP+Olapalil is more effective than TP chemotherapy alone in the treatment of platinum-sensitive advanced ovarian cancer,without increasing adverse reactions,promoting apoptosis and inhibiting angiogenesis,so it can be popularized.
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