Objective To analyze the significance of cervical biopsy and P1 6 protein detection in high-risk human papilloma virus(HPV)positive patients.Methods 76 cases of high-risk HPV-positive patients with cervical cytopathology and HPV-DNA diagnosis admitted to our hospital from July 2021 to June 2023 were selected as the study objects.After admission,cervical biopsy was performed and P16 protein was detected.Cervical biopsy and positive detection of P16 protein were analyzed.Results In 76 high-risk HPV-positive patients,chronic cervicitis accounted for 35.53％,high-grade squamous intraepithelial neoplasia accounted for 39.47％,and cervical cancer accounted for 25.00％.The clinical HPV typing test showed that the proportion of HPV16,52 and 31 was the highest,which was 26.32％,15.79％and 10.53％,respectively,and the proportion of HPV35 and HPV59 was the lowest,which was 2.63％and 1.32％(P＜0.05).The positive rate of P16 protein was 81.48％for chronic cervicitis,93.33％for high-grade squamous intraepithelial neoplasia,100.00％for cervical cancer,and 90.79％(P＞0.05).P16 protein was positively correlated with the diagnosis results of high-risk HPV positive cervical biopsy.Conclusions Cervical biopsy can determine the clinical classification of high-risk HPV-positive patients,and P16 protein is correlated with cervical biopsy results,which can be used to identify the risk of cervical cancer.
HPVHistopathological examinationP16 proteinCervical cancer
维普
万方数据
