摘要
目的 探讨降钙素原(PCT)、氨基末端脑钠肽前体(NT-proBNP)水平在急性心肌梗死(AMI)合并心力衰竭(HF)患者中的变化及其与心功能的关系.方法 本研究中共纳入 68 例AMI合并HF患者,所有病例均来源于安阳市第二人民医院,选取时间为2021 年10 月至2023 年10 月,进行回顾性分析,将所有AMI合并HF患者作为研究组,另选择同期在本院接受治疗的 60例AMI患者,将其作为参照组.将两组患者基线资料各项指标.血清PCT、NT-proBNP 指标,以及心功能指标进行检测.将两组患者各项基线资料进行对比,将研究组患者不同心功能分级患者血清学相关指标进行对比,采用相关性软件对血清PCT、NT-proBNP 指标与心功能指标的相关性进行分析.结果 AMI合并HF组患者血清PCT、NT-proBNP、左室舒张末期内径(LVEDD)、左房舒张末期前后径(LAED)指标水平均相较于AMI组上升,左室射血分数(LVEF)水平则相较于AMI组下降(均P<0.05),两组患者收缩压(SBP)、舒张压(DBP)、心率、总胆固醇(TC)、三酰甘油(TG)、高密度蛋白胆固醇(HDL-C)、低密度蛋白胆固醇(LDL-C)、白细胞计数(WBC)等指标水平经对比,未见明显差异(均P>0.05);Ⅳ级患者血清PCT、NT-proBNP 指标相较于Ⅲ级组患者明显上升,且Ⅲ级患者上述指标相较于Ⅱ级患者明显上升(均P<0.05);相关性软件分析结果得出,血清PCT、NT-proBNP 与LVEDD、LAED之间呈正相关(r=0.432、0.557、0.597、0.783,均P<0.05),而与LVEF指标均呈负相关(r=-0.400、-0.422,均P<0.05).结论 AMI合并HF患者血清PCT、NT-proBNP 水平异常上升,且不同心功能分级之间上述指标差异显著,血清PCT、NT-proBNP 与LVEDD、LAED之间呈正相关,而与LVEF指标均呈负相关,对PCT、NT-proBNP 指标进行检测可用于对AMI合并HF患者心功能状况予以评定.
Abstract
Objective To investigate the changes of procalcitonin(PCT)and amino-terminal brain natriuretic peptide precursor(NT-proBNP)levels in patients with acute myocardial infarction(AMI)combined with heart failure(HF)and their relationship with cardiac function.Methods A total of 68 patients with AMI combined with HF were included in this study,all cases were from the Second People's Hospital of Anyang City,selected from October 2021 to October 2023,and were analysed retrospectively,all patients with AMI combined with HF were considered as the study group,and another 60 patients with AMI who were treated in our hospital during the same period of time were selected,and were considered as the reference group.The indicators of baseline data of patients in both groups were taken.Serum PCT,NT-proBNP indicators,and cardiac function indicators were tested.The baseline data of the two groups of patients were compared,and the serological indicators of patients with different cardiac function grades in the study group were compared,and the correlation software was used to analyse the correlation between serum PCT,NT-proBNP indicators and cardiac function indicators.Results Serum PCT,NT-proBNP,left ventricular end-diastolic diameter(LVEDD)and left atrial end-pre-diastolic diameter(LAED)increased and left ventricular ejection fraction(LVEF)decreased in the AMI group compared with the AMI group(all P<0.05),and systolic blood pressure(SBP)and diastolic blood pressure(DBP)increased in the AMI and HF groups,The levels of systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate,total cholesterol(TC),triacylglycerol(TG),high-density protein cholesterol(HDL-C),low-density protein cholesterol(LDL-C),and white blood cell count(WBC)in the two groups were compared and did not show any significant difference(both P<0.05).The results of correlation software analysis showed that there was a positive correlation between serum PCT,NT-proBNP and LVEDD,LAED(r=0.432,0.557,0.597,0.783,all P<0.05),and a negative correlation with LVEF(r=-0.400,-0.422,all P<0.05),and a negative correlation with LVEF(r=-0.400,-0.422,all P<0.05).0.422,both P<0.05).Conclusion Serum PCT and NT-proBNP levels increased abnormally in patients with AMI combined with HF,and there were significant differences between different cardiac function grades,and there was a positive correlation between serum PCT and NT-proBNP and LVEDD and LAED,while there was a negative correlation with LVEF,so PCT and NT-proBNP indicators can be used to assess the cardiac function status of patients with AMI combined with HF.PCT and NT-proBNP can be used to assess the cardiac function of patients with Neoplasia(LGIN)and specific risk factors.
维普
万方数据