蛋白质琥珀酰化修饰的研究进展
Research progress on protein modification by lysine succinylation
刘怡 1马海东 1原夏萌 1莫莎 1程佳 1朱振东 2曾文先1
作者信息
- 1. 陕西理工大学生物科学与工程学院,陕西汉中 723001
- 2. 青岛农业大学动物科技学院,山东青岛 266109
- 折叠
摘要
蛋白质琥珀酰化修饰是通过酰化反应将琥珀酰基添加到蛋白质赖氨酸残基上.琥珀酰化修饰会影响蛋白质的结构和功能,进而调节信号传导和细胞代谢等生命活动.文章综述了蛋白质琥珀酰化修饰的位点分布、供体来源、琥珀酰基转移酶以及去琥珀酰化酶多个基本特征,并讨论了琥珀酰化修饰在能量代谢、细胞增殖、雄性生殖和自噬等生命活动中的重要作用,目的在于为进一步发现更多琥珀酰化修饰相关的酶与底物、了解其与琥珀酰化修饰相关的生物学功能提供参考.
Abstract
Protein succinylation in organisms is a process wherein a succinyl donor covalently binds a succinyl group to one or more protein lysine residues through enzymatic or non-enzymatic means,which leads to significant chemical and structural changes to the modified protein to regulate the metabolism and signal transduction in the cell.In this paper,the site distribution,donor source,succinyltransferase and desuccinylase of protein succinylation modification reviewed and the important role of succinylation in energy metabolism,cell proliferation,male reproduction and autophagy were discussed,aiming to provide a reference to discover more enzymes and substrates related to succinylation modification.
关键词
琥珀酰化修饰/转录/增殖/能量代谢/免疫/自噬/雄性生殖Key words
succinylation modification/transcription/proliferation/energy metabolism/immunity/autophagy/male repro-duction引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据