Colonic injury in mice caused by iron deficiency anemia (IDA)
To investigate the situation of IDA-induced colonic injury in mice, IDA mouse model was established in this paper. Serum, colon tissue and feces were collected at the end of the experiment, and pathological analysis of colon tissue, oxidative damage detection of serum and colon, and Illumina Miseq high-throughput sequencing of fecal flora were performed. Compared with the control group, IDA group mice had pathological changes such as colonic mucosal epithelial defect. TAC of the serum and colon tissues of IDA group mice decreased significantly, and the MDA content increased significantly 4 times (P<0.05), accompanied by lower intestinal microbial diversity and a change in the composition of the flora. Iron deficiency anemia can induce colonic epithelial structure defects, colonic oxidative damage, and changes in intestinal flora composition.
NETL
NSTL
万方数据
维普
