Latest development of proteolysis-targeting chimera for kinases
Protein kinase higly sought-aftr targets in current medicinal medicinal chemistry research.It plays a crucial role in the pathophysiological processes of various diseases including cancer,inflammation and autoimmune diseases.Therefore,there is significant interest in developing drugs that target protein kinase.While many effective kinase inhibitors have been developed and approved since the 1980s,they often encounter challenges such as drug resistance and non-targeting effect.To address these limitations.researchers devote to converting effective kinase inhibitors into proteolysis-targeting chimera(PROTAC),which offers the potential to conquer the resistance of molecule inhibitors by degrading target kinase selectively.Recent advancements in PROTAC technology applied to kinases are highly discussed,with a particular focus on compounds published since 2018.
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