This paper is an attempted to investigate the influence of leak-off factors on settling veloci-ty of proppants.The study is performed by coupling the R-Z model,the coefficient of resistance model and the leak-off velocity model in shale pores to establish a settling velocity calculation model influenced by leak-off factors in fractures,and exploring the effects of viscosity,pore radius,sliding length and sand ratio on the settling patterns of proppants.The results show that with the increase of the leak-off volume,the proppants rapidly reduce their settling velocity within 200 to 400 seconds;the settling velocity of proppants with different viscosities intersect due to leak-off,and then the viscosity and settling velocity show a positive correlation;compared with previous data,the prediction results of the model proposed have an average error of 13.88%,verifying the accuracy of the model.