Safety study on cefquinome sulfate intramammary infusion(lactating stage)in dairy cows
In order to evaluate the safety of cefquinime sulfate intramammary infusion(lactating stage)in dairy cows,in the experiment,twelve healthy lactating cows were selected,and one of the preparations(by C23 H24 N6 O5 S2,3 g∶75 mg)was injected into each milk area after milking,with injection interval of 12 h and three times in a row.In this experiment,the three dosing times were recorded as 0,12,and 24 h,respectively.The interval between 24 hours before administration and the two samples were recorded as-48 h and-24 h,respectively.The sampling time of 12 h after the third dose was recorded as 36 h.Day 7 after the third dose was recorded as 192 h.The clinical symptoms of the tested cows before and after administration were observed;the average daily milk yield,clinical symptom score,somatic cell count(SCC)and microbial number in milk,as well as the blood routine and serum biochemical indexes were counted to evaluate the safety of the preparation.The results showed that there were no abnormal signs in dairy cows after treatment,and there was no significant difference in average daily milk yield before and after treatment(P>0.05),and the SCC in milk was significantly higher at 12 h and 36 h than at-48 h,-24 h and 192 h(P<0.05),which reached the peak at 24 h,and was significantly higher than those at-48 h,-24 h,12 h,36 h and 192 h(P<0.05).The percentage of eosinophils at 192 h was significantly lower than that at-48 h,-24 h and 36 h(P<0.05).The average platelet volume at-48 h and-24 h was significantly lower than that at 36 h and 192 h(P<0.05),but within the normal physiological range.The creatinine concentration at 36 h was significantly lower than-48 h(P<0.05),and slightly increased at 192 h,but there was no significant difference with-48 h,-24 h and 36 h(P>0.05).Urea nitrogen/creatinine at 36 h was significantly higher at-48 h(P<0.05),and slightly decreased at 192 h,but there was no significant difference with-48 h,-24 h and 36 h(P>0.05).The results suggested that this preparation had a high safety for lactating dairy cows.
万方数据
维普
