Objective To explore the causes of tuberculin experimental reaction and nursing intervention measures.Methods 103 subjects who underwent tuberculin test in the outpatient department from June 2021 to October 2022 were selected as the study subjects,and the reactions of 103 subjects were counted,including the occurrence of local strong reactions and systemic reactions.Analyze the causes of various reactions,and put forward corresponding nursing intervention countermeasures according to the results of the analysis.Results In 103 patients,the reaction rate was 13.59%,of which 7.77%was local strong reaction and 5.83%was systemic reaction.The patients who responded did not cause serious adverse events after timely treatment.Local strong reactions include double loops,blisters,induration and lymphangitis,all of which are judged as positive reactions.Systemic reactions include fever,dizziness,hypotension and itching,which are related to the allergy after tuberculin test,the patient's mood,the patient's constitution,the injection room environment,drugs and diseases.Conclusion For tuberculin test patients,health education,investigation of past medical history and medication history,psychological intervention,environmental care,and observation of systemic adverse reactions should be strengthened in order to deal with them in time and avoid serious adverse events.