Objective To explore the effect of targeted nursing mode in abnormal uterine bleeding nursing.Methods A total of 96 patients with perimenopausal abnormal uterine bleeding from January 2021 to December 2021 were randomly divided into two groups.The control group was treated with conventional nursing mode,and the study group was treated with targeted nursing mode.Results Compared with the control group,the compliance rate of the study group was higher(P<0.05).The depression score and anxiety score of the two groups after intervention were lower than those before intervention(P<0.05).Compared with the control group,the depression score and anxiety score of the study group after intervention were lower(P<0.05).Compared with the control group,the satisfaction of the study group was higher(P<0.05).Conclusions The application of targeted nursing in the nursing of patients with abnormal uterine bleeding can effectively improve the compliance behavior of patients,effectively reduce the patients'bad psychological state,significantly increase the patient's satisfaction,the application effect is good,worthy of clinical application.