To study the different chemical constituents of Scutellariae Radix and Wine Radix Scutellariae.Methods:HPLC method was used to establish the fingerprint method of Scutellaria baicalensis tablets and 10 batches of Scutellariae Radix and Wine Radix Scutellariae(each).and the similarity evaluation system of Chinese Medicine Chromatographic Fingerprint(2012 edition)and spss17.0 software were used for similarity evaluation,CA andPCA.Results:The fingerprint similarity of Scutellariae Radix and Wine Radix Scutellariae was greater than 0.996,and there were 9 common peaks,4 of which were identified.According to the cluster analysis,the Scutellariae Radix could be divided into three groups:those from Hebei and Inner Mongolia,Shandong and Shanxi.By principal component analysis,the cumulative variance contribution rate of the two principal component factors was 94.29％,and the chromatographic peaks 1,2,4,5,6 and 7(Wogonoside)contributed significantly to the chemical composition difference of Scutellariae Radix and Wine Scutellariae Radix.Conclusion:The method established in this study is stable and accurate,which can provide a reference for the analysis of different chemical constituents of Scutellariae Radix and Wine Scutellariae Radix.
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