Objective:To analyze the effect of holistic nursing intervention on postoperative rehabilitation and prevention and control of complications in patients with gallstone surgery.Methods:114 patients with gallstones were selected as the study subjects,who underwent surgical treatment in our hospital from June 2019 to March 2023.The selected study subjects were divided into two groups using a randomized number table method as a grouping tool.The intervention mode used by the patients in the control group during the perioperative period was routine nursing intervention.The patients in the observation group were combined with a holistic nursing intervention mode after surgery.The time of ambulatory activity,initial postoperative exhaust time,and postoperative defecation time in the two groups were compared Postoperative extubation time,postoperative hospital stay,comfort,complications,and nursing satisfaction.Results:The postoperative rehabilitation indicators in the observation group were better than those in the control group,and the postoperative recovery time and hospitalization time were significantly shorter(P<0.05).There was no significant difference in comfort between the two groups before intervention(P>0.05).After intervention,the score and total score of the General Comfort Questionnaire(GCQ)in the observation group were higher than those in the control group(P<0.05).The total incidence of complications in the observation group and the control group after surgery was 15.79%and 3.51%,respectively,and the total incidence in the observation group was significantly lower(P<0.05).The total nursing satisfaction of the control group and the observation group was 87.72%and 98.25%respectively,and the observation group had higher satisfaction(P<0.05).Conclusion:The application of holistic nursing intervention model in postoperative patients with gallstone surgery can shorten the postoperative recovery time,improve the physical and mental comfort of patients,significantly reduce complications,and improve patient nursing satisfaction.