Objective:To study and analyze the impact of nursing interventions on sleep disorders in patients undergoing hemoperfusion and maintenance hemodialysis treatment.Methods:60 patients with hemoperfusion and maintenance hemodialysis who were admitted to Mount Wuyi Municipal Hospital from June 2021 to June 2022 were selected as observation samples,and all of them were treated with maintenance hemodialysis or intermittent hemoperfusion.According to the principle of randomization,the group was divided into a control group and an observation group with 30 cases each.The control group received routine nursing interventions,while the observation group received comprehensive nursing interventions.Result:Before the implementation of nursing strategies,there was no significant difference in the scores of anxiety and depression between groups(P>0.05);After implementing various intervention measures,the scores of negative emotions in both groups showed changes,and the scores in the observation group were even lower than those in the control group(P<0.05).After implementing nursing strategies,the proportion of 0-3 items with sleep disorders in the observation group was at a higher level,while other items were displayed at a lower level(P<0.05).Both groups were in the maintenance blood purification treatment stage,and the control group had a higher proportion of complications(P<0.05).Before implementing the nursing plan between groups,there was no significant difference(P>0.05)in the assessed nutritional index values of HB content,STB content,and ALB content;After implementing nursing measures,the tested values of nutritional composition indicators between groups improved,and the observed group had higher values than the control group(P<0.05).The proportion of patients in the observation group who were satisfied with the total satisfaction rate of nursing staff was larger,and the difference was significant compared to the control group(P<0.05).Conclusion:Implementing comprehensive nursing interventions in the treatment of patients with maintenance hemodialysis and intermittent hemoperfusion has a moderating effect on sleep disorders and adverse emotions,as well as reducing treatment complications and improving patient satisfaction and nutritional levels.