OBJECTIVE On the basis of the reported research review of Inonotus obliquus,to prepare effervescent tablets of Inonotus obliquus that have pharmacological effects,are easy to dissolve,and are healthy and delicious,and use Design-expert 11.0.4 software to prepare them the process is optimized.METHODS Combining Inonotus obliquus with modern tableting technology,combined with pharmaceutical excipients such as sodium bicarbonate,sweet orange flavor,lactose,etc.,to prepare effervescent tablets of Inonotus obliquus,and single-factor investigation of factors affecting the quality of tablets.Select three factors that have a greater impact on the tablet to conduct a 3-factor 5-level star point design-response surface method experiment,and use the Design-expert 11.0.4 software to optimize the formula to obtain the optimal plan.And conduct quality inspection on the optimized effervescent tablets.RESUITS The best process after optimization by star point design-response surface method is:the content of Inonotus obliquus is 30％,the content of is 30％,the mass ratio of sodium bicarbonate to tartaric acid is 1∶0.846,and the content of lactose is 7％,the content of mannitol and PEG-6000 is 2％.CONCLUSION The star point design response surface methodology was used to optimize the effervescent tablets of Inonotus obliquus,providing a necessary scientific basis for the development of Inonotus obliquus health food.The quality of the prepared Inonotus obliquus effervescent tablets is qualified and meets the requirements of the 2020 edition of the Pharmacopoeia of the People's Republic of China.
万方数据
维普
