Objective:To observe the clinical efficacy of medicationat the Anshentongluo therapy in treating Fengtanzuluo-post-stroke anxiety disorder(PSAD).Method:160 patients were randomized into 2 groups on average,the Anshentongluo therapy group was intervened by oral use of Anshentongluofang;and The Western medication group was intervened by oral use of fluoxertine hydrochloride.The therapeutic efficacy and side effects were evaluated with Hamilton Anxiety Scale(HAMA)and treatment emergent symptom scale(TESS).Results:After the intervention of 4 weeks,the HAMA decrease values in two groups were less than those before the treatment(P<0.01).There was on significant difference in response rate between the 2 groups.There was significant difference in TESS between the 2 groups.Conclusion:Anshentongluo therapy is one of the effective therapies with less emergent symptom in treating Fengtanzuluo-PSAD,which is worth studying and spreading further more.