ObjectiveTo systematically evaluate the clinical efficacy and safety of Dihuang Yinzi in the treatment of aphasia after stroke.MethodsRandomized controlled trial(RCTs)related to the treatment of aphasia after stroke by Dihuang Yinzi were collected through computer retrieval of databases such as CNKI,Wanfang,VIP,SinoMed,CBM,PubMed,Embase,etc.The basic information of the literature was extracted,and the quality and risk assessment were carried out.Finally,RevMan 5.3 software was used for Meta analysis.Result14 RCTs were ultimately included for meta-analysis,with a total of 986 patients(499 in the treatment group and 487 in the control group).Meta analysis results showe that:1.In terms of improving the score of Chinese Aphasia Rating Scale(ABC),Dihuang Yinzi combined with western medicine and rehabilitation therapy is superior to the simple western medicine and rehabilitation therapy[MD=10.78,95％CI(7.57,14.00),P＜0.0001];2.In terms of improving the grading standard of Aphasia severity(BDAE),Dihuang Yinzi combined with western medicine and rehabilitation treatment is superior to western medicine and rehabilitation treatment alone[MD=0.80,95％CI(0.14,1.46),P=0.02];3.In terms of improving Aphasia Quotient(AQ)scores,the combination of Dihuang Yinzi and Western medicine combined with rehabilitation treatment is superior to simple Western medicine combined with rehabilitation treatment[MD=12.93,95％CI(6.65,19.22),P＜0.000 01].ConclusionDihuang Yinzi has significant clinical efficacy in treating aphasia after stroke,improving patients'language function scores,improving their language dysfunction,and has relatively safe side effects.
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