Objective:To explore the application value of psychological counseling and psychiatric nursing in patients with depression.Methods:70 patients with depression admitted to our hospital from August 2021 to August 2023 were randomly divided into observation group(35 cases)and control group(35 cases).The control group received routine nursing,while the observation group received psychological counseling and psychiatric nursing.After the nursing intervention,the nursing satisfaction of the two groups was compared,and the improvement of sleep quality,bad mood and quality of life of the two groups before and after the intervention was compared.Results:compared with the control group,the nursing satisfaction of the observation group was higher;With statistical significance(p<0.05);Before the intervention,there was no significant difference in sleep quality,bad mood and quality of life between the two groups(p>0.05).After the intervention,the improvement effect of sleep quality,bad mood and quality of life in the observation group was better(p<0.05).Conclusion:the application value of psychological counseling and psychiatric nursing in patients with depression is very significant,which can obtain higher nursing satisfaction,help relieve their bad emotions,and improve their sleep and quality of life.