Objective:Exploring the clinical characteristics of pregnant women with Systemic Lupus Erythematosus(SLE)and analyzing the impact of SLE on pregnancy outcomes.Method:92 pregnant women with combined SLE admitted to the Obstetrics and Gynecology Department of Zhongshan Hospital Affiliated to Xiamen University from December 2016 to December 2022 were selected as the study group,and 71 normal pregnant women were selected as the control group.The basic information and nutritional status of the two groups were compared,and the medication situation before and after delivery for pregnant women with combined SLE inthestudygroupwas compared.Results:The adverse pregnancy outcomes of the study group were also compared.Compared with the control group,there was no significant difference in age,number of pregnancies,and number of deliveries between the study group and the control group.However,there was a significant difference in the history of adverse pregnancy and childbirth between the two groups(x2=6.457,P＜0.05);During the active period of the study group,there was a significant decrease in albumin and hemoglobin levels(x2=2.473,P＜0.05)(x2=3.767,P＜0.05),but there was no significant difference in BMI values(x2=6.457,P＞0.05);There is a significant increase in the use of oral prednisone and intravenous prednisolone after delivery in pregnancy with SLE(x2=3.115,P＜0.05)(x2=5.572,P＜0.05),while the increase in intravenous cyclophosphamide and oral hydroxychloroquine was not statistically significant(x2=0.583,P＞0.05)(x2=0.736,P＞0.05).In the study group,there was a significant increase in active pregnancy loss and pulmonary hypertension(PE)(x2=6.425 P＜0.05),(x2=6.029,P＜0.05),but there was no difference in postpartum hemorrhage(x2=1.413,P＞0.05).Conclusion:Pregnancy combined with SLE increases the adverse pregnancy history of pregnant women,affects their nutritional status,limits the use of hormones and immunosuppressants,increases complications such as lupus nephritis during active phase of pregnancy combined with SLE,and leads to increased adverse pregnancy outcomes such as fetal distress and premature birth.The research results of this paper can provide reference content for the later development of diagnostic and treatment standards for systemic lupus erythematosus in China in 2023.
NETL
NSTL
万方数据
