目的 探讨基于周围神经病变的运动模式(Exercise for Peripheral Neuropathy,EPN)改良版肢体运动训练对多发性骨髓瘤化疗致周围神经病变患者生活质量及周围神经病变的改善效果.方法 将多发性骨髓瘤化疗致周围神经病变患者61例按随机数字表法分为对照组和干预组.对照组进行常规基础运动训练,干预组进行EPN改良版肢体运动训练,持续4周.干预前后对两组生活质量、神经病变严重程度进行比较.结果 共59例患者(干预组31例,对照组28例)完成研究.干预后,干预组生活质量得分(107.23±12.21)分,周围神经病变严重程度得分[7.00(7.00,9.00)]分,对照组分别为(95.04±15.11)分、[9.00(9.00,10.00)]分,两组比较,差异有统计学意义(均P＜0.05).结论 基于EPN改良版肢体运动训练能提高多发性骨髓瘤化疗致周围神经病变患者生活质量,有效改善其周围神经病变情况,且简便易行,安全有效.
Effect of limb movement training in multiple myeloma patients with chemotherapy-induced peripheral neuropathy
Objective To explore the effect of modified limb movement training based on exercise for peripheral neuropathy(EPN)on quality of life and peripheral neuropathy in multiple myeloma patients with chemotherapy-induced peripheral neuropathy.Methods A total of 61 multiple myeloma patients with chemotherapy-induced peripheral neuropathy were divided into a control group and an intervention group by using a random number table.The control group received routine basic exercise training,while the interven-tion group received modified limb movement training based on EPN for 4 weeks.Quality of life and severity of peripheral neuropa-thy were compared between the two groups before and after the intervention.Results Totally 59 patients(31 in the intervention group and 28 in the control group)completed the study.After the intervention,the scores of quality of life and severity of peripheral neuropathy in the intervention group were(107.23±12.21)points and[7.00(7.00,9.00)]points,which were(95.04±15.11)points and[9.00(9.00,10.00)]points in the control group,there were statistically significant differences in the above scores between the two groups(both P＜0.05).Conclusion The modified limb movement training based on EPN can in-crease the quality of life in multiple myeloma patients with chemotherapy-induced peripheral neuropathy,effectively improve their peripheral neuropathy,and it is simple,safe and effective.
multiple myelomachemotherapyperipheral neuropathyexercise interventionlimb movement trainingquality of life
万方数据
维普
