淋巴瘤患者行干细胞移植联合CD30嵌合抗原受体T细胞输注治疗的护理

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中文摘要：目的总结6例复发/难治性CD30阳性淋巴瘤患者进行自体干细胞移植联合抗CD30嵌合抗原受体T细胞输注治疗的护理经验.方法对6例复发/难治性CD30阳性淋巴瘤患者,完善治疗前的护理评估,重点落实预处理毒性、细胞因子释放综合征以及植入综合征的护理,并将心理支持及健康教育纳入整个治疗过程.结果 6例患者均成功植入造血干细胞,外周血中检测到持续性CAR30转基因,其中5例完全缓解,1例部分缓解.5例出现细胞因子释放综合征,均为Ⅰ级,未观察到神经毒性.随访20.4(12.1,34.4)个月,患者均存活并保持其反应性.结论自体干细胞移植联合抗CD30嵌合抗原受体T细胞输注治疗具有良好的耐受性和高度活性,护理在治疗各阶段以及毒副反应管理中发挥重要作用.

外文标题：Nursing care of autologous stem cell transplantation combined with anti CD30 chi-meric antigen receptor T cell infusion for treatment of lymphoma patients

外文摘要：Objective To summarize the nursing experience of 6 patients with recurrent/refractory CD30 positive lymphoma under-going autologous stem cell transplantation combined with anti CD30 chimeric antigen receptor T cell infusion.Methods Six patients with recurrent/refractory CD30 positive lymphoma were evaluated for nursing care before treatment,focusing on the care of pre-treatment toxicity,cytokine release syndrome,and implantation syndrome.Psychological support and health education were inclu-ded in the entire treatment process.Results Hematopoietic stem cells were successfully implanted in all 6 patients.Persistent CAR30 gene transfer was detected in peripheral blood.Five cases had complete remission and 1 case had partial remission.Five pa-tients developed cytokine release syndrome,all of which were grade I,and no neurotoxicity was observed.At a median follow-up of 20.4(12.1,34.4)months,all patients survived and maintained their responsiveness.Conclusion Autologous stem cell transplanta-tion combined with anti CD30 chimeric antigen receptor T cell infusion therapy has good tolerance and high activity.Nursing plays an important role in various stages of treatment and in the management of toxic and side effects.

外文关键词：

Hodgkin lymphomaanaplastic large cell lymphomachimeric antigen receptor T cellsautologous hematopoietic stem cell transplantationcytokine release syndromeoral mucositisdiarrheahematology care

作者：

徐丽、万滢、阮海涛、雷路、陈琳

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作者单位：

华中科技大学同济医学院附属同济医院血液科(湖北武汉,430030)

关键词：

霍奇金淋巴瘤间变性大细胞淋巴瘤嵌合抗原受体T细胞自体造血干细胞移植细胞因子释放综合征口腔黏膜炎腹泻血液病护理

出版年：

2024

DOI：

10.3870/j.issn.1001-4152.2024.05.028

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