Risk factors analysis of perianal infection following allogeneic hematopoietic stem cell transplantation
Objective To analyze the risk factors for perianal infection following allogeneic hematopoietic stem cell transplantation(HSCT),and to provide a reference for the development of preventive and therapeutic strategies for perianal infections in clinical settings.Methods A total of 264 patients receiving bone marrow transplantation were selected and divided into an infection group and a non-infected group based on whether they developed perianal infections post-transplantation.Logistic regression analysis was used to explore the influencing factors of perianal infection following transplantation.Results The incidence of perianal infection af-ter allogeneic HSCT was 19.32％(51/264).Logistic regression analysis showed that previous history of diabetes,history of perianal disease before transplantation,undergoing a second transplantation,and the time to neutrophil engraftment were risk fac-tors for post-transplantation perianal infection,while regular use of protectants after sitz baths was identified as a protective factor(all P＜0.05).Conclusion The incidence of perianal infection following allogeneic HSCT is high.Healthcare providers should con-sider patient's medical history and comorbidities in their clinical assessments,especially focusing on patients undergoing a second transplantation.Particular emphasis should be placed on enhancing health education about perianal infection during the period of delayed neutrophil engraftment,and improving perianal infection protection measures,in a bid to reduce the incidence of perianal infection post-transplantation.
NETL
NSTL
万方数据
