异基因造血干细胞移植并发肛周感染的危险因素分析
Risk factors analysis of perianal infection following allogeneic hematopoietic stem cell transplantation
姚昱名 1王明明 2施香君 3邢晓慧 2雷店 2任抒文2
作者信息
- 1. 江苏大学附属人民医院护理部(江苏镇江,221000);江苏省军区徐州第四离职干部休养所
- 2. 江苏大学附属人民医院护理部(江苏镇江,221000)
- 3. 河北燕达陆道培医院骨髓移植中心
- 折叠
摘要
目的 分析异基因造血干细胞移植并发肛周感染的危险因素,为临床制定肛周感染的防治方案提供参考.方法 选取264例骨髓移植患者,按照移植后是否发生肛周感染分为肛周感染组和非感染组,采用logistic回归分析移植并发肛周感染的影响因素.结果 264例患者中,肛周感染组51例(19.32％).回归分析显示,既往有糖尿病史、肛周疾患史、二次移植、中性粒细胞植入时间为移植后并发肛周感染的危险因素,坐浴后规律使用保护剂为保护因素(均P＜0.05).结论 异基因造血干细胞移植并发肛周感染的发生率较高,护理人员应重视既往病史、并存疾病的影响,重点针对二次移植的患者,尤其是在中性粒细胞未成功植入期间,加强肛周感染知识的健康宣教,做好肛周感染防护,减少移植并发肛周感染的发生率.
Abstract
Objective To analyze the risk factors for perianal infection following allogeneic hematopoietic stem cell transplantation(HSCT),and to provide a reference for the development of preventive and therapeutic strategies for perianal infections in clinical settings.Methods A total of 264 patients receiving bone marrow transplantation were selected and divided into an infection group and a non-infected group based on whether they developed perianal infections post-transplantation.Logistic regression analysis was used to explore the influencing factors of perianal infection following transplantation.Results The incidence of perianal infection af-ter allogeneic HSCT was 19.32％(51/264).Logistic regression analysis showed that previous history of diabetes,history of perianal disease before transplantation,undergoing a second transplantation,and the time to neutrophil engraftment were risk fac-tors for post-transplantation perianal infection,while regular use of protectants after sitz baths was identified as a protective factor(all P＜0.05).Conclusion The incidence of perianal infection following allogeneic HSCT is high.Healthcare providers should con-sider patient's medical history and comorbidities in their clinical assessments,especially focusing on patients undergoing a second transplantation.Particular emphasis should be placed on enhancing health education about perianal infection during the period of delayed neutrophil engraftment,and improving perianal infection protection measures,in a bid to reduce the incidence of perianal infection post-transplantation.
关键词
血液病/造血干细胞移植/肛周感染/肛周护理/危险因素/糖尿病/二次移植/感染防护Key words
hematologic diseases/hematopoietic stem cell transplantation/perianal infection/perianal care/risk factors/diabetes/second transplantation/infection protection引用本文复制引用
基金项目
国家自然科学基金青年项目(81900177)
出版年
2024
NETL
NSTL
万方数据