Analysis of the effectiveness and safety of stereotactic intracerebral nucleus lesion in the treatment of elderly Parkinson's disease patients
Objective:To investigate the effectiveness and safety of stereotactic intracerebral nucleus lesion in the treatment of elderly Parkinson's disease patients.Methods:44 elderly patients with primary Parkinson's disease in one hospital were selected as the research subjects,they were divided into the control group and research group using random number table method,22 cases in each group.The control group was treated with dopamine hydrazine tablets,while the research group received stereotactic intracerebral nucleus lesion on the basis of the control group,the treatment results were evaluated 6 months later.The scores of the Parkinson's Disease Comprehensive Rating Scale(UPDRS),Autonomous Neurological Symptom Scale(SCOPA AUT),Berg Balance Scale(BBS),and the levels of neurological function related indicators before and after treatment and clinical efficacy after treatment were compared between the two groups,the incidence of postoperative complications in the research group was recorded.Results:Compared with before treatment,the scores of UPDRS Ⅰ,Ⅱ and Ⅲ after 6 months of treatment decreased in both groups,and the research group was lower than the control group(P<0.05);The total effective rate of the research group after treatment was higher than that of the control group(P<0.05).Compared with before treatment,the SCOPA-AUT scores decreased and the BBS scores increased after 6 months of treatment in both groups,and the research group was better than the control group(P<0.05).Compared with before treatment,the serum level of BDNF increased,and the levels of S-100β,NSE decreased after 6 months of treatment in both groups,and the research group was better than the control group(P<0.05).The research group experienced 1cases of postoperative dysarthria or language ambiguity,1 case of delirium,all patients were discharged smoothly.Conclusion:Stereotactic intracerebral nucleus lesion can improve the neurological function of elderly Parkinson's disease patients,enhance their daily living ability and motor function after surgery,with good results and high safety,it is worth promoting and using in elderly Parkinson's disease patients.
NETL
NSTL
万方数据
