丘脑底核脑深部电刺激术联合小剂量多巴丝肼治疗帕金森病的临床疗效及对焦虑抑郁、睡眠障碍的影响
Clinical effect of deep brain stimulation with subthalamic nucleus combined with low dose of dopaminazide in treatment of Parkinson's disease and its influence on anxiety,depression and sleep disorders
司昊天 1李永全 1任虹宇 1王晓斌 1张小广 1马建功 1何承1
作者信息
- 1. 河南大学第一附属医院神经外科,河南开封 475000
- 折叠
摘要
目的:探索丘脑底核脑深部电刺激术(STN-DBS)联合小剂量多巴丝肼治疗帕金森病(PD)的临床疗效及对焦虑抑郁、睡眠障碍的影响.方法:将81例PD患者作为观察对象,依治疗意愿随机分为研究组(n=41)和对照组(n=40).对照组给予多巴丝肼治疗,研究组在对照组治疗基础上加用STN-DBS治疗.观察两组患者治疗前和治疗6 mon的帕金森病综合评估量表(UPDRS)评分、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD-17)评分、帕金森氏睡眠量表(PDSS)评分、匹兹堡睡眠质量指数(PSQI)评分、药物剂量变化及不良反应.结果:研究组的临床总有效率95.12％高于对照组(P＜0.05);两组治疗 6 mon,患者的 UPDRS-Ⅰ、UPDRS-Ⅱ、UPDRS-Ⅲ 评分、HAMD-17 评分、HAMA评分、PDSS评分和PSQI评分均明显低于治疗前,研究组各项指标均显著低于对照组(P＜0.01).研究组治疗后,可减少患者左旋多巴等效计量及药物不良反应的发生率.结论:STN-DBS联合小剂量多巴丝肼治疗PD疗效确切,可改善患者运动能力,提高日常生活活动能力、改善焦虑抑郁情绪和睡眠障碍,减少抗PD药物剂量和药物不良反应.
Abstract
Objective:To explore the clinical efficacy of subthalamic nucleus deep brain stimulation(STN-DBS)combined with low dose of dopaminazide in the treatment of Parkinson's disease(PD)and its influence on anxiety,depression and sleep disorders.Methods:A total of 81 PD patients were selected as observation objects and randomly divided into study group(n=41)and control group(n=40)according to their willingness to treat.The control group was given dopasehydrazine treatment.The research group was treated with STN-DBS on the basis of the treatment of the control group,and the Parkinson's Disease Comprehensive Assessment Scale(UPDRS)score,Hamilton Anxiety Scale(HAMA)score,Hamilton Depression Scale(HAMA)score before treatment and 6 months after treatment in the two groups were observed.Scale(HAMD-17)score,Parkinson's Sleep Scale(PDSS)score,Pittsburgh Sleep Quality Index(PSQI)score,drug dose changes and adverse reactions.Results:The total clinical effective rate of the study group was 95.12％higher than that of the control group(P＜0.05);the UPDRS-Ⅰ,UPDRS-Ⅱ,UPDRS-Ⅲ scores,HAMD-17 scores,HAMA scores,The PDSS score and PSQI score were significantly lower than those before treatment,and the indexes in the study group were significantly lower than those in the control group(P＜0.01).After treatment in the study group,the equivalent dose of levodopa in patients could be reduced.Conclusion:STN-DBS combined with dopasehydrazine is effective in the treatment of PD.It can improve patients'exercise ability,improve activities of daily living,improve anxiety,depression and sleep disorders,and reduce the dose of anti-PD drugs and adverse drug reactions.
关键词
帕金森病/丘脑底核脑深部电刺激术/焦虑/抑郁/睡眠障碍Key words
Parkinson's disease/subthalamic nucleus deep brain stimulation/anxiety/depression/sleep disorders引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据