首页|pH敏感脂质体在肿瘤治疗领域的研究进展

pH敏感脂质体在肿瘤治疗领域的研究进展

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pH敏感脂质体作为药物或核酸的载体可以在肿瘤部位选择性释放药物,减少抗肿瘤药物或核酸在血液循环过程中的释放,降低对正常组织的毒副作用,提高药物/核酸的生物利用度.本文对近五年来用于治疗肿瘤的pH敏感脂质体的研究进行了综述,介绍了 pH敏感脂质体的制备方法、响应机制和应用,为pH敏感脂质体在抗肿瘤药物载体设计方面的研究提供参考.
Advances in pH-sensitive liposomes for cancer therapy
As one of drug or gene carriers,pH-sensitive liposome can selectively release drugs at tumor tissues,reduce the drug leakage during the blood circulation,reduce side effects of drugs,leading to enhanced drug bioavailability.The references on pH-sensitive liposomes in five years are summarized to use for cancer therapy,and introduce the preparation methods,response mechanism and application of pH-sensitive liposomes,and provide references for the research of pH-sensitive liposomes in the design of anti-tumor drug carriers.

pH-sensitive liposomedrug carriercancer therapy

昌天鹤、全姬善

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延边大学融合学院,吉林延吉 133002

延边大学药学院,吉林延吉 133002

pH敏感脂质体 药物载体 肿瘤治疗

2024

河南大学学报(医学版)
河南大学

河南大学学报(医学版)

影响因子:0.494
ISSN:1672-7606
年,卷(期):2024.43(3)